CDH2 and neoplasm: We also conducted immunohistochemical analysis of E-cadherin, N-cadherin, and Vimentin in tumor tissues of orthotopic xenograft model mice and verified that ADE treatment decreased the expression of E-cadherin and increased the expression of N-cadherin and Vimentin in the orthotopic tumors (Fig. 3g, e), indicating the transition of cells from an epithelial to a mesenchymal phenotype in the tumor tissue.