Our study has revealed that DNA damage stress triggered by 5-FU, DOX, or γ-irradiation elevates ARTS mRNA level in cancer cells (Fig. 1E–G, L) and in vivo (Fig. 2), which is consistent with a previous study showing that treatment of SH-SY5Y cells with Etoposide upregulates ARTS expression38. The gene discussed is SEPTIN4; the disease is cancer.