Even though we could not provide direct mechanistic evidence that the improved endothelial function was due to secreted factors by CM, our study did show that neutrophil infiltration was attenuated; immunoreactivity against caspase-3, caspase-8, and caspase-9 proteins was decreased; and ICAM-1 and VCAM-1 gene expression had regressed in vascular grafts from BD animals submitted to IR injury. Here, CASP9 is linked to Behcet disease.