TLR4 signalling can also be induced by the DAMPs abundant in cholesteatoma tissue e.g. high-mobility group box 1 proteins (HMGB1) [66], Tenascin [67], fibronectin [5], S100A8, S100A9 [68] and also HSP60 and HSP70 [69]. Here, S100A8 is linked to cholesteatoma.