In gastric cancer, DDX3X binds the transcription factor YY1 (yin yang 1) with the help of the circRNA circ-CTNNB1, which results in the transactivation of YY1 and the subsequent activation of genes involved in WNT/β-catenin signalling, thereby promoting tumour progression (Fig. 5) [51]. The gene discussed is YY1; the disease is gastric cancer.