Evidence has shown that DDX3X is overexpressed in glioma, medulloblastoma (MB), meningioma, head and neck squamous cell carcinoma (HNSSC), lung cancer, breast cancer, hepatocellular carcinoma (HCC), gallbladder carcinoma, pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC), prostate cancer and sarcoma [27–29, 77, 79, 83, 85, 89, 90, 95, 98, 99, 104, 105]. This evidence concerns the gene DDX3X and head and neck squamous cell carcinoma.