In terms of some particular genes, microglia can increase the expression of toll-like receptor genes (Tlr1, Tlr2, Tlr7) that mediate the inflammatory response in persistent pain.49 Previous reports in two different neuropathic pain model indicate that LRP increases Tlr2 expression further from the initial increase caused by either pain model.12,32 This is congruent with this study. The gene discussed is TLR2; the disease is neuropathic pain.