Tumor cell‐intrinsic PD‐L1 promoted basal mTORC1 activity as PD‐L1KO MB49 cells showed decreased activation (phosphorylation) of mTORC1 downstream targets RPS6 and 4E‐BP1 versus control MB49 cells and reduced phosphorylated mTOR (Figure 5A,B), consistent with our prior data from melanoma and ovarian cancer cells.13 This evidence concerns the gene CD274 and melanoma.