Programmed death‐ligand 1 (PD‐L1) is an immune cosignaling molecule that negatively regulates T‐cell functions through its known receptors programmed death 1 (PD‐1) and CD80,1 and is immunopathogenic in many cancers, including bladder cancer (BC).2, 3, 4. The gene discussed is CD274; the disease is urinary bladder cancer.