CD274 and melanoma: However, AKTS473 phosphorylation was also reduced in PD‐L1KO MB49 cells (Figure 5C), consistent with PD‐L1‐driven mTORC2 activation, in contrast to the increased AKTS473 phosphorylation we reported in PD‐L1‐depleted melanoma and ovarian cancer, but similar to PD‐L1 effects in human ES2 ovarian cancer cells.13