TP53 and head and neck squamous cell carcinoma: To understand the potential role of FGFR3 in both HPV-positive and -negative SCCHN, we examined FGFR3 protein expression in two cohorts of SCCHN patients consisting mostly of OPSCC and examined the correlation with mutant p53 (mp53) and HPV status using p16 as a surrogate biomarker for HPV.