MME and cancer: CD10 (neutral endopeptidase), a zinc-dependent metalloproteinase, is expressed in various normal tissues and is capable of efficiently degrading various peptides and cytokines.(11–14) CD10 is also expressed in malignant tumors and has been identified as a predictor of tumor biological aggressiveness through extracellular enzymatic degradation and intracellular signaling crosstalk.(15–25) CD10 is expressed in MM,(26) and patients present with a poorer prognosis than negative cases.