G609G mice showed aberrant connexin-43 (Cx43) localization, indicated by significantly below-normal N-Cadherin (N-Cadh)/Cx43 colocalization (Figure 1C), in agreement with our previous data in Zmptse24−/− mice,9 HGPS pigs,11 and HGPS patients.9 Here, CDH2 is linked to Hutchinson-Gilford progeria syndrome.