The activation of cytosolic cysteine proteases causes caspase activation, resulting in apoptosis.7 In the our study, although caspase 3 and caspase 9 activities and apoptosis were observed in human DBTRG glioblastoma cells in the amalgam with LCu or HCu groups, caspase 3 and caspase 9 expression and apoptosis levels were decreased by Se and/or CpZ treatments. This evidence concerns the gene CTSB and glioblastoma.