Relevant markers are cluster of differentiation (CD) 14, CD163, CD68 or hypoxia‐inducible factor 2α (HIF‐2α).(78, 79, 80) A combination of analyzes of cell surface markers, cytokines secreted by TAMs and soluble factors produced by other cells within the TME could be useful to determine specific cell expression profiles in CRC. Here, EPAS1 is linked to colorectal carcinoma.