In stage II colon cancer, a higher proportion of CD206 positive macrophages (M2‐like subtype, anti‐inflammatory) in relation to the overall density of macrophages (CD206/CD68 ratio) is associated with poor disease‐free & overall survival rates.A higher proportion of anti‐inflammatory M2‐like macrophages (higher CD206/CD68 ratio) is associated with beneficial effects on survival in stage II colon cancer patients that receive adjuvant chemotherapy. This evidence concerns the gene CD68 and malignant colon neoplasm.