Furthermore, signal transducer and activator of transcription 3 (STAT3) activation leads to M2 polarization of macrophages.(68) This pathway can be induced by glucagon‐like peptide 1 (GLP‐1), a postprandially secreted hormone that improves insulin resistance.(68) TAMs also promote tumor development by inducing interleukin 10 (IL‐10) production in CRC cells through a STAT3 pathway(69, 70) and produce cytokines such as VEGF to induce tumor angiogenesis and tumor growth.(71). This evidence concerns the gene STAT3 and colorectal carcinoma.