TIMP1 and colorectal carcinoma: Serum levels of neutrophil elastase within the TME have been shown to play a potential role as a diagnostic biomarker in CRC.(81) While serum matrix metalloproteinase‐9 (MMP‐9) was not considered to be an appropriate screening parameter for CRC,(82) tissue inhibitor of metalloproteinase‐1 (TIMP‐1) seems to have a potential diagnostic value.(83) Targeting related factors that are expressed by TAMs or neighboring cells within the TME and circulatory markers may further contribute to the overall diagnostic capacity.