Irrespective of the availability of oxygen, they metabolize glucose to lactate, which is also secreted to induce VEGF and arginase 1 (ARG1) expression in TAMs.(66) VEGF expression in macrophages was shown to be upregulated by a pathway described in hypoxia, even under normoxic conditions.(66) This mechanism leads to macrophage recruitment and polarization toward the tumor promoting M2 macrophage phenotype and is therefore associated with metabolic reprogramming in TAMs. The gene discussed is VEGFA; the disease is neoplasm.