Characterized by the stabilization and transcription of HIFs,5 the increased production of factors such as VEGFs, angiopoietin 2 and IL8 maintains a proangiogenic and pathologic microenvironment for tumour cells3, 6, 7 and modulates the autocrine and paracrine effects of the cytokine response towards the tumour.7 The gene discussed is ANGPT2; the disease is neoplasm.