FLG and colorectal carcinoma: Meanwhile, we also defined 15 FMGs in Chinese CRC patients from the ICGC cohort, including APC (46%), TP53 (44%), TTN (38%), KRAS (36%), and MUC6 (33%), MUC16 (26%), ZNF717 (25%), MUC4 (24%), SYNE1 (21%), FRG1 (20%), MUC17 (18%), FAT4 (18%), FLG (18%), OBSCN (17%) and MUC3A (17%; Figure 1B).