During the progression of cervical cancer, other down‐regulated genes, such as synaptonemal complex protein 2 (SYCP2)(Gene ID: 10388) has been found that it is expressed uncontrolled in early oral cancer of human HPV infection,42 and SYCP2 gene alternative splicing events may be involved in the occurrence and development of uterine CSCC, and can be used as a bio‐diagnostic marker for CSCC.43 The gene discussed is SYCP2; the disease is skin squamous cell carcinoma.