This microarray included 24 normal specimens, 14 cervical intraepithelial neoplasia 1 (CIN1) lesions, 22 CIN2 lesions, 40 CIN3 lesions and 28 cancer specimens, and found top 24 candidate biomarkers which were highly or lowly expressed in different histological grades, with KRT17 and CRISP2 being the most significant. This evidence concerns the gene CRISP2 and cancer.