Therefore, this study hypothesized that thrombocytopenia in patients with sepsis was associated with increased plasma Ang II and that treatment with angiotensin II receptor blocker (ARB) would attenuate sepsis‐induced platelet apoptosis and improve septic thrombocytopenia in a murine model of lipopolysaccharide (LPS)‐induced endotoxemia. The gene discussed is AGT; the disease is serum lipopolysaccharide activity.