For instance, interleukin 13 (IL-13) peptide can specifically bind with high affinity to IL-13 Rα2, a tumor-specific receptor overexpressed in GBM.[81] A study[82] showed that nanoparticles modified with IL-13 were accumulated at higher levels in the tumor, because of an increased internalization of the nanoparticles in glioma cells. The gene discussed is IL13; the disease is glioblastoma.