This can be achieved using a ligand that interact with both BBB and glioma cells, such as the LDL receptor-related protein (LRP), Tf, or the α7 nicotinic acetylcholine receptor.[85–87] In the study conducted by Zheng et al.,[87] a peptide that binds to α7 nicotinic acetylcholine receptors has been used, attached to the liposomal surface. This evidence concerns the gene CHRNA7 and central nervous system cancer.