To further explore the molecular mechanism by which miR-128-3p regulates the biological functions in sepsis, the expression levels of proteins related to the Smad signaling pathway (Smad2 and Smad3) were measured in controls cells and LPS-induced HK2 cells transfected with NC, miR-128-3p, miR-128-3p + vector, or miR128-3p + TGFBR2. This evidence concerns the gene SMAD2 and Sepsis.