ITCH and Familial prostate cancer: So far, circ-ITCH has been proved to be implicated in prostate cancer [19, 20], ovarian cancer [21–24], bladder cancer [25], breast cancer [26], lung cancer [27], oral squamous cell carcinoma [28], gastric cancer [29], hepatocellular carcinoma [30], glioma [31], and multiple myeloma [32].