The mRNA levels of all nine DEGs, except for RPL23, decreased in the blood of AD mice compared to those in the blood of WT mice (RPL23: p = 0.5657; ACTG1: p = 0.0188; DDX5: p = 0.0268; RPS6KB2: p < 0.0010; ALDOA: p = 0.0046; NOL6: p < 0.0010; EFHD2: p = 0.0188; HERPUD1: p < 0.0010; PRRT1: p = 0.0222; Figure 5a). This evidence concerns the gene HERPUD1 and Alzheimer disease.