Our qPCR results indicated that the mRNA levels of RPL23 (p = 0.0050) in blood significantly increased in patients with AD, whereas mRNA levels of ACTG1 (p = 0.0136), DDX5 (p = 0.0348), RPS6KB2 (p < 0.0010), ALDOA (p < 0.0010), NOL6 (p < 0.0010), EFHD2 (p < 0.0010), HERPUD1 (p < 0.0010), and PRRT1 (p = 0.0424) significantly decreased compared to those in the NEC group (Figure 3a), and the change in the expression of these genes was in line with the results of the GSE data analysis. The gene discussed is EFHD2; the disease is Alzheimer disease.