Meanwhile, the expression of the nine DEGs in the hippocampi of AD and WT mice were also measured, and the results showed that the expression levels of all DEGs decreased in the hippocampi of AD mice compared to those in their control littermates (RPL23: p = 0.0034; ACTG1: p = 0.0021; DDX5: p < 0.0010; RPS6KB2: p < 0.0010; ALDOA: p = 0.0086; NOL6: p < 0.0010; EFHD2: p < 0.0010; HERPUD1: p < 0.0010; PRRT1: p < 0.0010; Figure 5b). The gene discussed is PRRT1; the disease is Alzheimer disease.