For instance, Rg3 combined with sorafenib or oxaliplatin had synergetic effects on inhibiting proliferation, promoting apoptosis, and decreasing tumor volume via regulating the PTEN/Akt signaling pathway or proliferation cell nuclear antigen (PCNA)/cyclin D1 expression, which are key regulators of many cellular processes [95, 96]. The gene discussed is CCND1; the disease is neoplasm.