AKT1 and glioblastoma: Rh2 reduced proliferation, apoptosis, and metastasis via downregulating miR-31 to suppress Wnt/β-catenin signaling and Akt activities, thereby blocking the activation of matrix metalloproteinase (MMP)13, a major degradation enzyme in Daoy medulloblastoma and glioblastoma cells [72, 78].