TF and bipolar disorder: Recently, large-scale neurogenomic studies have identified a large number of expression quantitative trait loci (eQTL) SNPs and de novo mutations associated with psychiatric disorders including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD).76,77 In these studies, the effects of the identified variants were mostly explained by their ability to alter chromatin structure and TF binding.