We also prioritized two VUS in BEST1 gene that affect two cases with Macular Dystrophy; VUS NM_004183.3: c.828C > G, reported as pathogenic in VarSome, and, VUS NM_001139443.1: c.671A > G with other described pathogenic variants in the same amino acid. Here, BEST1 is linked to Macular dystrophy.