PHS2 association with age at aggressive prostate cancer diagnosis in ProtecT was similar to that previously reported for PHS1 (z = 21.7, p = 3.6 × 10−104 for PHS1; z = 21.4, p = 1.3 × 10−101 for PHS2). The gene discussed is PTGS1; the disease is Familial prostate cancer.