PLOD1 and male infertility: During the 8-week long treatment, weekly blood biochemical analyses revealed no major changes in hormonal (LH and testosterone) levels (Supplementary Fig. 6), blood chemistry (Supplementary Fig. 7), liver (Supplementary Fig. 8), or kidney (Supplementary Fig. 9) functions, suggesting that oral intake of triptonide at 0.1 mg/kg BW for 8 weeks causes male infertility without systemic side effects in adult male cynomolgus monkeys.