RB1 and neoplasm: In general, some tumor suppressor genes, such as p53 and pRb, prevent normal cells from becoming carcinogenic by acting on the cell cycle and promoting genetic changes; it is therefore common for tumor cells to present an aberrant-splicing activity with an increased frequency of splicing isoforms that maintain the abnormal proliferative and apoptotic rhythm.77 Alternative splicing participates in the process of proliferation, differentiation and apoptosis via regulating the alternative expression of many oncogenic or tumor suppressor genes,78 as well as splicing factors.