SRSF2 and chronic myelomonocytic leukemia: As early as in 1990, SRSF2 was first discovered in HeLa cells and was identified as a non-snRNP protein-splicing component.106 The SRSF2 mutations often occur in the linking sequence of the RNA-recognition motifs (RRM) and RS regions, the mutations of which affect exons by recruiting U2AF to the upstream 3′ SS and U1 snRNP to the downstream 5′ SS.107,108 Studies have shown that mutations in SRSF2 have been found in hematological malignancies, with the highest frequency occurring in chronic myelomonocytic leukemia (CMML; 28–47%), and the lowest in MDS.109