ESRP1 and hnRNPM could compete for GU-rich binding sites in the pre-mRNA and modulate exon inclusion or skipping, defining either an epithelial or a mesenchymal state to determine a specific cell fate.89 It was recently revealed that hnRNPM and ESRP1 are key regulators in the EMT splicing program and are correlated with breast cancer.90 Here, ESRP1 is linked to breast carcinoma.