SF3B1 and B-cell chronic lymphocytic leukemia: Mutations of SF3B1 were first found in patients with MDS.113 It was also found that mutations in SF3B1 were closely associated with the presence of ring sideroblasts in MDS, suggesting that mutations in SF3B1 are associated with refractory anemia with RARS.56 Wang et al.114 found that mutations in SF3B1 caused dysfunction in cells, including DNA damage, affecting Notch signaling, etc., thus indicating that it is associated with poor prognosis of CLL.