Wingless (Wnt) signaling is well known for regulating development and stemness, and for its close association with many cancer types, especially colorectal cancer (CRC).151 Glycogen synthase 3β is part of the canonical Wnt pathway and has been reported to direct the phosphorylation of splicing factors, such as SRSF2152 or PTB-associated splicing factor (PSF).153 Activated Wnt/β-catenin signaling could directly enhance the transcript level of SRSF3.154 SRSF3 has also been reported to negatively affect one alternative exon inclusion variant of RAS-related C3 botulinum toxin substrate 1b.155. The gene discussed is SFPQ; the disease is colorectal carcinoma.