AKT1 and lung carcinoma: For example, activated AKT has been shown to phosphorylate SRSF1 in lung cancer cells, thereby generating an anti-apoptotic caspase-9b isoform through the exclusion of an exon 3,4,5,6 cassette.147 EGF signaling was reported to regulate splicing through the phosphorylation of AKT/SRPK/SR protein148 and/or SPSB1-hnRNPA1 ubiquitination.149 The PI3K/AKT pathway is also known to activate the mammalian target of rapamycin complex 1 (mTORC1), a key regulator of cell metabolism and growth.