ESRP1 and breast cancer: ESRP1 and hnRNPM could compete for GU-rich binding sites in the pre-mRNA and modulate exon inclusion or skipping, defining either an epithelial or a mesenchymal state to determine a specific cell fate.89 It was recently revealed that hnRNPM and ESRP1 are key regulators in the EMT splicing program and are correlated with breast cancer.90