The inhibitory effect of taurine-conjugated BAs on ER stress, which is reportedly vital for HSC function29,32, and the aforementioned finding that ENT3, an intracellular BA transporter, is indispensable for HSPC survival suggested that the observed recovery from anemia and lethality in vivo may depend on ENT3-BA interplay utilizing ENT3’s natural substrate in circulation. This evidence concerns the gene SLC29A3 and anemia.