Multiple studies indicate that perturbed SST-signaling, and a loss of SST-positive neurons are both linked to elevated depressive-like/anxiety-like behaviors, and vulnerability of SST neurons to damage has also been suggested in the context of major depressive disorder (Carmichael and Lockhart, 2012; Lin and Sibille, 2015; Douillard-Guilloux et al., 2017; Fee et al., 2017). The gene discussed is SST; the disease is major depressive disorder.