While syndromic variants of primary progressive aphasia (PPA) [20] have some predictive value of underlying proteinopathy, the most common clinical phenotype, i.e. behavioral-variant FTD (bvFTD) [59], corresponds to roughly equal frequencies of FTLD-Tau and FTLD-TDP proteinopathies at autopsy. The gene discussed is MAPT; the disease is behavioral variant of frontotemporal dementia.