There was some heterogeneity within proteinopathy groups that reflects previous qualitative studies, with greatest WM tau pathology burden in CBD compared to other tauopathies [32], and particularly minimal WM TDP-43 pathology burden in FTLD-TDP type C that was lower than the other TDP subtypes [36, 53], including type E [35]. The gene discussed is TARDBP; the disease is proteostasis deficiencies.