TARDBP and amyotrophic lateral sclerosis: Concordantly, postmortem observations in ALS with relatively focal TDP-43 pathology find WM TDP-43 pathology limited to oligodendrocytes in close proximity to degenerating axons from motor nuclei [5, 7], while others find no evidence of deep corticospinal tract TDP-43 pathology in oligodendrocytes, suggesting that WM pathology may contribute minimally to disease severity in ALS [14, 31].