LFAR1, a liver-enriched lncRNA, binds to Smad2/3 and promotes the transcription of genes involved in liver fibrosis, including Smad2/3, Notch2/3, and TGFB. Therefore, this lncRNA activates TGFβ/Notch signaling pathway and promotes liver fibrosis in HFD mice [140]. The gene discussed is SMAD2; the disease is Hepatic fibrosis.