It has been discovered many genes and pathways in the pathogenesis of NAFLD, including binding immunoglobulin protein (BIP), inositol-requiring transmembrane kinase/endonuclease (IRE), C/EBP homologous protein (CHOP), X-binding protein (XBP), acetyl–coenzyme A carboxylase enzyme (ACC), sterol regulatory element binding proteins 1c (SREBP-1c), lipoprotein lipase (LPL), stearoyl–coenzyme A desaturase 1 (SCD1), fatty acid synthase (FASN), tumor necrosis factor-α (TNFA), and monocyte chemoactive protein 1 (MCP1) [19]. Here, DDIT3 is linked to metabolic dysfunction-associated steatotic liver disease.