In AML-M2, chloroacetate esterase (CAE), α-naphthyl butyrate esterase (ANBE), alkaline phosphatase (ALP), and SBB on peripheral blood smears revealed an 94% of blast cells positives for CAE, occasional positive cells for ALP, and blast cells negative for NBE and SBB [15]. The gene discussed is GJA8; the disease is acute myeloid leukemia.