In the presence of gastrointestinal manifestations as the most prominent and severe sign (anorexia, nausea, vomiting, diarrhea, abdominal pain, deviation from the morphometric curve), it is necessary to eliminate the presence of an IBD (primarily Crohn’s disease) or any other cause of ulcerative colitis, including deficiencies of IL10 and IL10R, MKD, and HA20 and anomalies of chromosome 8. The gene discussed is IL10; the disease is ulcerative colitis.