In conclusion, FBXO1 and CDC20, PLK1, CCNB1, CCNA2, CDK1, KIF2C, KIF23, BUB1, BUB1B, MAD2L1 may be tightly functional partners in regulating breast tumor cell cycle process and mediating poor prognosis of BC together. The gene discussed is CCNB1; the disease is breast cancer.