The purpose of this study was to further determine the role of TRIM47 in the development and progression of RCC by immunohistochemical staining of RCC specimens, construction of TRIM47-overexpression plasmids, lentiviral shTRIM47 knockdown cell line, and Crispr/cas9 technology to construct knockout methods such as TRIM47 stably transformed strains, animal experiments, mass spectrometry detection, bimolecular fluorescent complimentary experiments and co-immunoprecipitation experiments, in an attempt to gain deeper insights into the molecular biological function and mechanism of TRIM47 in RCC. Here, TRIM47 is linked to renal cell carcinoma.