SMAD4 and non-small cell lung carcinoma: TRIM47 overexpression could promote the occurrence of non-small cell lung cancer (NSCLC) [14], and TRIM47 could play the role of E3 ligase by interacting with SMAD4 to promote SMAD4 ubiquitination and degradation, which further increased the level of CC motif chemokine ligand 15 (CCL15) and CC motif chemokine receptor 1 (CCR1), ultimately leading to poor prognosis of colorectal cancer [15].