For example, Seko N et al. examined the expression and distribution of OLFM4 in CRC by immunohistochemistry and found that34% of CRC cases were positive for OLFM4 cytoplasmic staining [25]; Liu W et al. reported that OLFM4 overexpression could alter the morphology and cortical actin distribution of HT-29 cells and decrease cell adhesion and migration [26]. This evidence concerns the gene OLFM4 and colorectal carcinoma.