In this study, we detected BRAF protein expression in EC tissues, studied the effect of BRAF on the invasion and metastasis of TE-1 (human esophageal cancer cell) cells in vitro, and explored the value of the BRAF gene in early EC diagnosis as well as the possibility of predicting prognosis to a provide theoretical basis for using BRAF inhibitors as targeted drugs in EC treatment. The gene discussed is BRAF; the disease is esophageal cancer.