On the univariate logistic regression analyses, older age, diabetes/ insulin resistance, dyslipidemia, arterial hypertension, MetS, higher serum levels of AST, ALT, alkaline phosphatase, GGT, and lower serum levels of total cholesterol and LDL were associated with significant liver fibrosis (≥ stage 2 fibrosis) (Table 5). The gene discussed is GPT; the disease is metabolic syndrome.