In a stepwise multivariate logistic regression analysis, older age (p < 0.0001, OR 1.103, 95% CI 1.073–1.134), lower serum levels of total cholesterol (p < 0.0001, OR 1.026, 95% CI 1.016–1.036), higher serum levels of ALT (p < 0.0001, OR 1.028, 95%CI 1.017–1.038), and alkaline phosphatase (p = 0.004, OR 1.019, 95% CI 1.006–1.032) remained independently associated with significant liver fibrosis (Table 5). The gene discussed is GPT; the disease is Hepatic fibrosis.