Analyzing the associations of PNPLA3 polymorphisms in patients with HCV, we found that GG subjects had lower BMI than CG/ CC individuals (25.19 ± 3.7 vs. 27.9 ± 5.24 vs. 27.67 ± 4.94, p = 0.046), and that the presence of MetS was more frequent in CC/CG subjects (p = 0.013) (Table 3). The gene discussed is PNPLA3; the disease is metabolic syndrome.