TXN2 and Sepsis: It has been seen that in sepsis conditions, where there is a severe oxidative environment, the TRX-2 system takes on a greater role, because it has been seen that proteins of the TRX-2 system were more resistant to the effects of oxidative stress and have a more important role in protecting against mitochondrial dysfunction than the GSH system, under conditions of sepsis in human endothelial cells in culture [15].