P73 encodes a transcription factor expressed in differentiating CRC (figure 4), the choroid plexus and the ependyma [58,59] and its knock-out in mice results in a phenotype very similar to the early loss of Sox2 in FoxG1-Cre cKO, with a lack of HF and almost absent DG [36]. Here, SOX2 is linked to colorectal carcinoma.