At E12.5, Tbr2 is expressed, in controls, by INP in the DNE and in CR cells towards the pia (figure 4a); in the FoxG1-Cre cKO mutant, whereas Tbr2 expression in CRC (towards the pia, arrow) appears present, expression in the DNE is not detected (figure 4a). This evidence concerns the gene EOMES and colorectal carcinoma.