In the FoxG1-Cre cKO, Reelin expression (marking CRC) is greatly reduced, and an HF is not observed (figure 3d); in Emx1-Cre cKO, Reelin is reduced, but the HF is visible (figure 3e), and in Nestin-Cre cKO, Reelin appears slightly reduced, but with a normal-looking distribution around the HF (figure 3f). Here, NES is linked to colorectal carcinoma.