To investigate the effect of regulating miR‐433‐FXYD3‐PI3K‐AKT signalling by KDM5A on HCC tumorigenesis, Hep3B and MHCC97H cells were subjected to subcutaneous injection in nude mice after being transfected with KDM5A shRNA. This evidence concerns the gene KDM5A and hepatocellular carcinoma.