To investigate the role of KDM5A in HCC angiogenesis, we silenced KDM5A in Hep3B and MHCC97H found si‐KDM5A‐1 achieving the best knock down efficiency in Hep3B cells, while si‐KDM5A‐3 was suitable for MHCC97H cells (Figure 2A). Here, KDM5A is linked to hepatocellular carcinoma.