While the decreased incidence of hypertension in participants with two Val49Ile variants in this dataset is encouraging, the lack of additional clinical benefits (e.g., decreased glucose, insulin, and triglycerides, as seen in fructose restriction and/or clinical KHK inhibition), as well as the fact that this association was not statistically significant among only white participants, complicates interpretation and application of the data. Here, INS is linked to hypertensive disorder.