Although these 131 shared exons generally display low inclusion in normal nonneural tissues compared with neural (Fig 7B), enrichment analysis confirmed that they were significantly overrepresented among the exons decreasing in all 9 cancer types (p < 0.05, 1-sided Fisher Exact test), further validating the silencing of SRRM4 target exons in tumors. The gene discussed is SRRM4; the disease is cancer.