In support of our hypothesis, we observed a negative correlation (RSpearman = −0.36, p < 2.2e-16, Fig 4B) between the MI and SRRM4 expression in tumor samples, while a positive correlation was observed at the promoter methylation level (RSpearman = 0.45, p < 2.2e-16, Fig 4C). This evidence concerns the gene SRRM4 and neoplasm.