ITGAM and chronic hepatitis B virus infection: As both children and adults with HBeAg+ IA and IT chronic hepatitis B were included in our study, we had an opportunity to examine if age may play a role in hepatic immune composition and phenotype in patients with HBeAg+ chronic hepatitis B. In fact, older age was associated with increased hepatic accumulation of Kupffer cells and CD11b+ cells, as well as with adaptive immune activation.