CDX2 and Hyperglycemia: Immunofluorescence micrographs showed thatCDX2 overexpression alleviates hyperglycemia-induced RTECs damage, and CDX2 knockdown induces the damages (Supplementary Figure 4), and overexpression of CDX2 in vivo can alleviate glomerular damage and renal tubular lesions during DKD (Supplementary Figure 5).