DVL2 and diabetic kidney disease: This was confirmed in the renal tissue; in normal kidney or DKD, CFTR can interact with Dvl2, but CFTR-Dvl2 complex amounts are low due to reduced CFTR amounts and increased Dvl2 during DKD; in this case, unbound Dvl2 may act as a transmission molecule for the Wnt signaling pathway, eventually activating β-catenin.