Therefore, the identification of ELK1 via miR-134 and PTBP1 in chemoresistance of osteosarcoma cells to DXR may aid in facilitating the existing understanding of the mechanisms of osteosarcoma, with potential of serving as a prognostic marker for the chemotherapeutic treatment of osteosarcoma in the future. Here, PTBP1 is linked to osteosarcoma.