Genetic evidence has further implicated polymorphisms—Apa1 (rs7975232), Fok1 (rs2228570), and Bms1 (rs1544410)—in the vitamin D receptor (VDR) gene to be responsible for hypovitaminosis D, suggesting that host genetic factors may be the cause of hypovitaminosis D in humans, as previously reported by Santos et al [33]. The gene discussed is VDR; the disease is rickets.