Discovering the role of VDR polymorphism in the occurrence of vitamin D deficiency and insufficiency among patients with SARS-CoV-2 infection will provide insight into how the clinical benefits of vitamin D supplementation can be optimized for those infected and/or hospitalized due to COVID-19 to reduce mortality, accelerate recovery from the illness, and promote health among people in Nigeria. This evidence concerns the gene VDR and vitamin D deficiency.