Recently, genetic studies show that partial loss-of-function variants of at least two components of human exocyst complex, EXOC7 and EXOC8, are associated with a recessively inherited disorder characterized by brain atrophy, seizures, and developmental delay, and in severe cases, microcephaly and infantile death (Coulter et al., 2020). The gene discussed is EXOC8; the disease is microcephaly.