The leading PAFs for ARD in PLWHs were declined eGFR (39.68%, 95% CI 17.41–55.83%) and CD4 count<200 cells/μL (39.61%, 95% CI 26.59–50.43%), which were higher than that of diabetes (10.19%, 95% CI 5.04–15.05%) (Figure 4). The gene discussed is CD4; the disease is diabetes mellitus.