Moreover, IL‐1β has been shown to play a major role in the induction of trained immunity,7, 12 which is also highlighted by Van der Meer et al., who demonstrated that treating mice with small doses of recombinant human IL‐1β reduces mortality in granulocytopenic mice from subsequent Pseudomonas infection, a concept at that time termed nonspecific resistance to infection.27 The gene discussed is IL1B; the disease is infection.