For example, small‐molecule inhibitor P5091 inhibits USP7 in colon cancer and chronic leukemia,16, 17, 34 and small‐molecule inhibitor b‐AP15 plays a significant role in inhibiting the cell growth of leukemia and esophageal squamous cell carcinoma.35, 36. The gene discussed is USP7; the disease is malignant colon neoplasm.