Based on the mechanisms of involvement of the USP family in many solid tumors,14, 32, 33 we can speculate that USP41 acts through regulating MDM2, Cyclin D1, FAS, and TGFBR1, which promote tumor cell survival and proliferation, inhibit cell apoptosis, promote cell migration, and may be associated with the beta‐catenin signaling pathway. This evidence concerns the gene TGFBR1 and neoplasm.